Authors: Panaitescu Denis Mihaela, Usurelu Catalina Diana, Oprica gabriela Mădălina, Gabor Augusta Raluca, Frone Adriana Nicoleta
Company/Institution: NATIONAL INSTITUTE FOR RESEARCH & DEVELOPMENT IN CHEMISTRY AND PETROCHEMISTRY – ICECHIM BUCHAREST
Country: Romania
e-mail: office@icechim.ro
web: www.icechim.ro
Severe oxygen deprivation can cause significant problems in chronic wounds, during organ preservation and implantation, or in cases of trauma, hemorrhagic shock, or viral pneumonia. Currently, there is no viable solution to deliver oxygen to the grafts during the healing period. The scope of the CELGAS project is to develop innovative oxygen-carrying systems capable of supplying oxygen in a controlled manner to injured tissue/ implants. The innovative oxygen-carrying systems will ensure controlled release of oxygen for long periods of time, will have a high stability, biodegradability, will not be cytotoxic and will have a nanometric size, essential to avoid vascular obstruction. In CELGAS, the problem will be addressed using nanocellulose and nanocellulose/biopolymer to encapsulate oxygen-generating species or to obtain oxygen-containing nanobubbles.
This work was financially supported by the Ministry of Research, Innovation and Digitization, CNCS/CCCDI–UEFISCDI, through the projects PN-III-P4-PCE2021-0435, contract 77PCE/2022 (CELGAS) within PNCDI III. It is also acknowledged the support of Ministry of Research, Innovation and Digitization through Program 1 – Development of the national research-development system, Subprogram 1.2-Institutional performance- Projects to finance excellence in RDI, Contract no. 15PFE/2021.