Anthraquinone from Vietnamese Morinda Citrifolia L.alleviate gout pain via NLRP3 inflammasome inhibition

Authors: Vu Phuong Linh, Nguyen Hoang Duong, Nguyen Le Ha Chi, Dang Lam Yen Nhi

Company/Faculty/School: The Key Laboratory of Enzyme and Protein Technology - VNU University of Science

Country: Vietnam


Anthraquinone from Vietnamese Morinda Citrifolia L. regulated MSU-induced activation of the NLRP3 inflammasome.

Anthraquinone (40 mg/kg) significantly suppressed ankle swelling from MSU-induced gout through inhibition of systemic inflammatory cytokine levels. Furthermore, anthraquinone represents potential candidate drugs for the management of gout in the clinic.